One-way adjustable loop suture constructs and methods of forming and using the same

ABSTRACT

Disclosed are surgical constructs and methods of use for a one-way adjustable fixation loop that is formed by tying two knots in a surgical filament, each knot defining an individual adjustable loop and the individual adjustable loops being interconnected to form the one-way adjustable fixation loop. The knots enable a non-spliceable suture to be used in the creation of the one-way adjustable fixable loop. Embodiments can include a fixation device, such as a cortical button or plate for use in a bone tunnel, and enable the knots to work independent of and suspended below the fixation device. Embodiments can increase the compatibility of the adjustable fixation loop with existing fixation devices and can isolate and protect the knots from damage during use and after implantation.

FIELD

The application relates generally to devices and methods for securingsoft tissue (e.g., ligament, tendon, graft) to bone, and moreparticularly to suture constructs that employ particular loopconfigurations that are adjustable in one direction.

BACKGROUND

Ligaments are the fibrous tissue that connects bones to other boneswithin the body. Tissue detachment may occur in many ways, e.g., as theresult of an accident such as a fall, overexertion during a work-relatedactivity, during the course of an athletic event, or in any one of manyother situations and/or activities. These types of injuries aregenerally the result of excess stress or extraordinary forces beingplaced upon the tissues. When ligaments are damaged, surgicalreconstruction can be necessary, as the ligaments may not regenerate ontheir own. In the case of a partial detachment, commonly referred tounder the general term “sprain,” the injury frequently heals withoutmedical intervention, the patient rests, and care is taken not to exposethe injury to undue strenuous activities during the healing process. If,however, the ligament or tendon is completely detached from itsattachment site on an associated bone or bones, or if it is severed asthe result of a traumatic injury, surgical intervention may be necessaryto restore full function to the injured joint.

A number of surgical procedures exist for re-attaching ligaments, orother soft tissue, to bone. One example is the knee 100 shown in FIG. 1,which includes anterior and posterior cruciate ligaments 102, 104extending from the head of the tibia 106 to the intercondylar notch ofthe femur 108. These ligaments operate to prevent forward and backwardrelative motion between the two bones. When ruptured (e.g., as canhappen in strenuous athletic movements), surgical reconstruction can benecessary.

Tears in the cruciate ligaments of the knee can be repaired using aligament graft taken from a cadaver (i.e., an allograft) or from apatient's own tissue (i.e., an autograft). Reconstruction proceduresgenerally involve forming a hole in both the femur and tibia, and thensecuring opposite ends of the ligament graft in these holes. In onecruciate ligament repair procedure, a ligament graft is associated witha surgical implant and secured to the femur. A common femoral fixationmeans includes an elongate “button,” sometimes referred to as a corticalbutton. The cortical button is attached to a suture loop that is sizedto allow an adequate length of the soft tissue graft to lie within thefemoral tunnel while providing secure extra-cortical fixation.

Existing devices and methods can be limited because they do not alwaysprovide the desired strength or adjustability. In some instances, forexample, one or more knots tied to help maintain a location of thesuture loop with respect to a cortical button, and thus the graftassociated therewith, can loosen or slip. Thus, even if a ligament graftis disposed at a desired location during a procedure, post-operativelythe circumference of the loop can increase, causing the graft to moveaway from the desired location. Further, it can be desirable to limitthe number of knots used in conjunction with such devices, because ofthe potential for the knots loosening and because the additional surfacearea of the knots can increase the risk of trauma to surrounding tissue.Still further, existing devices and methods also lack adjustability inmany instances. For example, in procedures in which multiple ligamentgrafts are associated with the cortical button, it can be difficult tocontrol placement of one ligament graft without also moving the otherligament graft.

Current adjustable cortical buttons used in orthopedics employing knotsare dependent on button geometry and/or multiple loops to achievesecurity. These are limiting factors for the versatility of the devicesand raise potential difficulty in usability. Splices have been used asone-way fixation elements to try and address these concerns, however,such configurations are limited at least because they are not amiable totape, sutures with tight sheaths and/or cores, and generally require alonger length of the loop to achieve security, thereby increasing theminimum adjustable length. Moreover, in use with purely suspensoryfixation devices (e.g., cortical button without locating/retentionfeature), location or migration of the button with respect to the bonetunnel, possibly caused by offloading of the device due to anon-isometric repair, can cause a reduced interference area on one sideof the device, reducing the fixation strength.

Accordingly, there is a need for improved graft fixation devices andmethods for use in repair and reconstruction procedures that include,for example, the cruciate ligaments of the knee. In particular, there isa need for devices and methods for positioning and securing ligamentgrafts that provide increased strength and adjustability withoutsplicing suture or using suture that cannot be spliced.

SUMMARY

The present disclosure is directed to a suture construct that has aone-way adjustable loop. The suture construct can be formed from asingle suture filament and, in at least some embodiments, can be coupledto one or more fixation bodies (e.g., cortical buttons) for use invarious soft tissue repair procedures. The single suture filamentincludes at least two knots formed therein, and at least two loopportions. Each loop portion extends from a respective knot, and then thetwo loop portions are interconnected to form the one-way adjustableloop. They can be interconnected, for example, by passing one loopportion through an opening defined by the other loop portion. Slidingtails formed from the suture filament and extending from the knots canbe operable to constrict or otherwise make the loop portions smaller,which in turn constricts or otherwise makes smaller the adjustable loop.Further, constricting tails formed from the suture filament andextending from the knots can be operable to constrict the knots, therebypreventing the sliding tails from sliding with respect to the knots.When the constricting tails constrict the knots, the loop portions, andthus the adjustable loop, cannot be expanded. In at least someembodiments, the constricting tails form a bridge portion that extendsbetween the two knots with the bridge portion keeping the construct in alocked configuration such that the one-way adjustable loop can beconstricted but not expanded.

The constructs disclosed herein can be used in various surgical repairprocedures in which soft tissue is to be disposed at desired locationswith respect to bones. Procedures in which a ligament or graft isdesigned to be disposed in a bone tunnel can benefit from the presentlydisclosed constructs and implant devices, such as ACL and MCL repairs.The present disclosure also allows for beneficial use in other types ofrepairs, including but not limited to AC joint repairs, bunion repairs,and ankle syndesmosis repairs.

In one exemplary embodiment, a suture construct formed from a suturefilament includes a first knot formed in the suture filament, a firsttail of the suture filament that extends from the first knot, a brideportion of the suture filament, a second knot formed in the suturefilament, and a second tail of the suture filament that extends from thesecond knot. The first knot creates a first loop that extends from thefirst knot, with the first loop defining a first loop opening. Thebridge portion extends from the first knot, connecting the first knot tothe second knot. The second knot creates a second loop that extends fromthe second knot, with the second loop defining a second loop opening,and a portion of the second loop passing through the first loop openingto define an adjustable loop of the suture construct. The adjustableloop defines an adjustable loop opening. The first tail is configured toslide with respect to the first knot to reduce a size of the first loopopening, and thus reduce the size of the adjustable loop opening.Similarly, the second tail is configured to slide with respect to thesecond knot to reduce a size of the second loop opening, and thus reducethe size of the adjustable loop opening. The bridge portion isconfigured to prevent expansion of the adjustable loop opening when thesuture is manipulated into a locked configuration.

At least one of the first knot or the second knot can be a self-lockingknot. Non-limiting examples of such knots include a FIG. 8 noose knot,an expanded FIG. 8 noose knot, and a prusik-style knot. The suturefilament can be unspliced at locations of the first and second knots. Insome embodiments, a second suture filament can be configured to capturea portion of the knot and/or knots to permit a release of the knot'sconstriction when traction is applied to the second filament. In oneexemplary embodiment of this configuration the second filament isthreaded through the first knot and the second knot, with a first limbof the second suture filament extending through the first knot and asecond limb of the second suture filament extending through the secondknot such that tension on the limbs loosens the respective first and/orsecond knots.

A fixation body can be coupled to the bridge portion of the suturefilament. For example, the bridge portion can be passed through aplurality of through-holes disposed in the fixation body. In someembodiments, a second fixation body can be coupled to the adjustableloop.

The suture can also include an unlocked configuration. In some suchembodiments, the suture can be configured to be moved between theunlocked configuration and the unlocked configuration by adjustingrelative loading of the bridge portion and/or the tail portion (i.e.,the first tail and the second tail). In one exemplary embodiment of asurgical implant, the implant includes a fixation body and a suturefilament coupled to the fixation body. The fixation body has alongitudinal axis extending therealong, first and second sides, andfirst and second through-holes. The suture filament includes a firstportion having a first tail, a first knot formed on the first portion,and a first loop portion. The first tail extends through the firstthrough-hole, the first knot is disposed on the first side of the body,and the first loop portion extends from the first knot, away from thebody. The suture filament also includes a second portion having a secondtail, a second knot formed on the second portion, and a second loopportion. The second tail extends through the second through-hole, thesecond knot is disposed on the first side of the body, and the secondloop portion extends from the second knot, away from the body. Thesecond loop portion is coupled to the first loop portion to define anadjustable loop of the surgical implant. The suture filament furtherincludes a bridge portion that extends from the first knot to the secondknot. The first and second knots are configured such that tension on thefirst tail constricts the adjustable loop by constricting the first loopportion and tension on the second tail constricts the adjustable loop byconstricting the second loop portion. The first and second knots arefurther configured such that tension on the bridge portion preventsexpansion of the adjustable loop.

At least one of the first knot or the second knot can be a self-lockingknot. Non-limiting examples of such knots include a FIG. 8 noose knot,an expanded FIG. 8 noose knot, and a prusik-style knot. The suturefilament can be unspliced at locations of the first and second knots.

In some embodiments, the bridge portion can extend from the first knot,through the first through-hole, across the body, and through the secondthrough-hole to the second knot. The implant can include a secondfixation body, in which case the second fixation body can be coupled tothe adjustable loop. The fixation body, or bodies, can include acortical button(s). In some embodiments, the fixation body can include athird through-hole. In some such embodiments, as well as in embodimentsthat include a second fixation body but do not necessarily include athird through-hole, the surgical implant can include a second suturefilament that captures a portion of the first knot and the second knot,with a first limb of the second suture filament extending through thefirst knot, and a second limb of the second suture filament extending tothe second knot. The second suture filament can be configured such thattension on at least one of the first or second limbs loosens therespective first or second knots.

One exemplary method for preparing a surgical implant includes forming afirst knot in a first portion of a suture length to form a first tailextending from one side of the first knot and a second portion of thesuture length extending from an opposite side of the first knot. Themethod further includes forming a first loop from the second portionwith the first loop being closed by way of the first knot. Stillfurther, a second knot is formed in the second portion of the suturelength to form a second tail extending from one side of the second knotand a third portion of the suture length extending from an opposite sideof the second knot. The method further includes forming a second loopfrom the third portion, the second loop being closed by way of thesecond knot, and the second loop being interconnected with the firstloop to define an adjustable fixation loop of the suture construct.

The second portion of the suture length can include a bridge portionthat extends between the first knot and the second knot. In someembodiments, at least one of the first tail or the second tail can beconfigured to constrict a size of an opening defined by the adjustablefixation loop when tension is applied to the tail(s) to constrict a sizeof first or second openings defined by the respective first or secondloops.

The method can also include passing the first tail through a firstthrough-hole of a fixation body, passing the second tail through asecond through-hole of the fixation body, and passing the second portionof the suture length through at least two of: (1) the first through-holeof the fixation body; (2) the second through-hole of the fixation body;(3) another through-hole of the fixation body; or (4) still anotherthrough-hole of the fixation body. Still further, the method can includecoupling the adjustable fixation loop to a second fixation body.

BRIEF DESCRIPTION OF DRAWINGS

This disclosure will be more fully understood from the followingdetailed description taken in conjunction with the accompanyingdrawings, in which:

FIG. 1 is a schematic side view of the anatomy of a human knee;

FIG. 2 is a side view of one exemplary embodiment of an adjustablefixation implant;

FIG. 3 is a perspective view of a fixation body of the adjustablefixation implant of FIG. 2;

FIG. 4A is a side view of a suture construct of the adjustable fixationimplant of FIG. 2, the suture construct having a one-way adjustableloop;

FIG. 4B is a detailed side view of a portion of the suture construct ofFIG. 4A that includes two FIG. 8 noose knots;

FIG. 5 is a side view of the adjustable fixation implant of FIG. 2having a second fixation body coupled to the suture construct, thesuture construct being further illustrated in FIG. 4A;

FIG. 6 is a schematic side view of one exemplary embodiment of forming aFIG. 8 noose knot;

FIG. 7A is a detailed side view of a portion of a suture constructsimilar to the suture construct of FIG. 4A, the suture constructincluding the FIG. 8 noose knot of FIG. 6 disposed in an adjustingorientation;

FIG. 7B is a detailed side view of the portion of the suture constructof FIG. 7A disposed in a locking orientation;

FIG. 8A is a detailed side view of a portion of a suture constructsimilar to the suture construct of FIG. 4A, the suture constructincluding an extended FIG. 8 noose knot in an adjusting orientation;

FIG. 8B is a detailed side view of the portion of the suture constructof FIG. 8A disposed in a locking orientation;

FIG. 9A is a detailed side view of a portion of a suture constructsimilar to the suture construct of FIG. 4A, the suture constructingincluding a single prusik style knot;

FIG. 9B is a detailed side view of one exemplary embodiment of a sutureconstruct similar to the suture construct of FIG. 4A, the sutureconstruct including a one-way adjustable loop constructed using at leasttwo prusik style knots (as shown, four such knots);

FIGS. 10A-10C are schematic side views of steps of one exemplaryembodiment of a method for tightening a one-way adjustable loop;

FIG. 11 is a schematic side view of one exemplary embodiment of anadjustable fixation implant disposed in a femur;

FIG. 12A is a perspective view of the suture construct of FIG. 4A, thesuture construct being associated with two fixation bodies;

FIG. 12B is a perspective view of the suture construct of FIG. 4A, thesuture construct being associated with two fixation bodies;

FIG. 12C is a perspective view of the suture construct of FIG. 4A, thesuture construct being associated with two fixation bodies;

FIG. 13 is a side view of one exemplary embodiment of an adjustablefixation implant that includes the suture construct of FIG. 4A coupledto the fixation body of FIG. 3, the suture construct also including autility stitch; and

FIGS. 14A-14C are schematic side views of steps of one exemplaryembodiment of a method of using the adjustable fixation implant of FIG.13.

DETAILED DESCRIPTION

Certain exemplary embodiments will now be described to provide anoverall understanding of the principles of the structure, function,manufacture, and use of the devices and methods disclosed herein. One ormore examples of these embodiments are illustrated in the accompanyingdrawings. Those skilled in the art will understand that the devices andmethods specifically described herein and illustrated in theaccompanying drawings are non-limiting exemplary embodiments and thatthe scope of the present disclosure is defined solely by the claims. Thefeatures illustrated or described in connection with one exemplaryembodiment may be combined with the features of other embodiments. Suchmodifications and variations are intended to be included within thescope of the present disclosure. Further, in the present disclosure,like-numbered components of the embodiments generally have similarfeatures. Additionally, to the extent that linear or circular dimensionsare used in the description of the disclosed systems, devices, andmethods, such dimensions are not intended to limit the types of shapesthat can be used in conjunction with such systems, devices, and methods.A person skilled in the art will recognize that an equivalent to suchlinear and circular dimensions can easily be determined for anygeometric shape. Sizes and shapes of the systems and devices, and thecomponents thereof, can depend at least on the anatomy of the subject inwhich the systems and devices will be used, the size and shape ofcomponents with which the systems and devices will be used, and themethods and procedures in which the systems and devices will be used.

The figures provided herein are not necessarily to scale. Further, tothe extent arrows are used to describe a direction a component can betensioned or pulled, these arrows are illustrative and in no way limitthe direction the respective component can be tensioned or pulled. Aperson skilled in the art will recognize other ways and directions forcreating the desired tension or movement. Likewise, while in someembodiments movement of one component is described with respect toanother, a person skilled in the art will recognize that other movementsare possible. Additionally, a number of terms may be used throughout thedisclosure interchangeably but will be understood by a person skilled inthe art. By way of non-limiting example, the terms “suture,” “filament,”and “suture filament” may be used interchangeably.

The present disclosure is generally directed to methods and devices forsecuring soft tissue, including but not limited to ligaments, tendons,and grafts, to bone or other desired locations within a subject (e.g.,human, animal). Surgical implants described herein generally include abody or fixation body, such as a “cortical button,” and a sutureconstruct formed from a suture (also referred to as a filament or suturefilament) threaded through, or otherwise associated with, the body in amanner that provides a one-way adjustable loop. The one-way adjustableloop can be formed by two interconnecting loops of suture (see, e.g.,loop portions 501, 503 of FIGS. 2 and 4). The size of the one-wayadjustable loop can be adjusted by manipulating one or both of theinterconnecting loops of suture using terminal ends of the suture. Inuse, a graft, and/or other tissue (e.g., ligament(s), tendon(s)), can becoupled to or otherwise associated with the one-way adjustable loop, forinstance by placing the tissue through an opening defined by the one-wayadjustable loop, with the one-way adjustable loop extending from afixation body of an implant. The tissue can be securely positionedwithin a bone tunnel by placing and securing the fixation body outsideof the tunnel and securing the position of the one-way adjustable loopafter it has been adjusted to a desired size, and thus desired location,to maintain a location of the graft with respect to the bone tunnel.

FIG. 2 is an illustration of one exemplary repair implant 600 thatincludes a surgical construct 400 coupled to or otherwise associatedwith a fixation body, as shown a cortical button 200. The surgicalconstruct includes a one-way adjustable loop 550 that can be formed bytwo loop portions 501, 503 interconnected with each other. The implant600 is arranged with a first tail 502 of the surgical construct 400passing through a second through-hole 212 of the body 200 (see FIG. 3 tobetter see the second through-hole 212) and a second tail 504 passingthrough a first through-hole 210 of the body 200 (see FIG. 3 to bettersee the first through-hole 210). The tails 502, 504 extend from knots520, 540 formed on the surgical construct 400, with the knots 520, 540being disposed on a same side of the body 200 as the one-way adjustablefixation loop 550. The knots 520, 540 and/or the through-holes 212, 210can be sized in a manner such that the knots 520, 540 cannot easily passthrough the through holes 212, 210. Additionally, a bridge portion 505(see FIGS. 4A and 4B) can extend between the first and second knots 520,540. For example, in conjunction with the implant as illustrated in FIG.2, a bridge portion 505 can extend from the first knot 520, though thesecond through-hole 212, across an opposite face of the body 200 (ascompared to the one-way adjustable fixation loop 550), though the firstthrough hole 210, and to the second knot 540. Alternatively, and moreakin to the illustration of the suture construct 400 provided in FIGS.4A and 4B, the bridge portion 505 can extend directly between the twoknots 520, 540 without passing through, over, across, and/or in contactwith the body 200. The fixation loop 550 is considered a one-way loopbecause a force applied to the loop 550, such as by applying it to thebody 200, to expand the one-way adjustable fixation loop 550 is resistedby the bridge 550, constricting the knots 520, 540 and preventing thetails 502, 504 from sliding.

In the configuration illustrated in FIG. 2, tension on either of thefirst or second tails 502, 504, such as being applied by a force in adirection D on either or both of the tails 502, 504, can reduce a sizeof openings 507, 509 defined by the loop portions 501, 503 associatedwith the respective tails 502, 504 and knots 520, 540. As the size ofthe openings 507 and/or 509 reduce, so too does a size of an opening 552defined by the one-way adjustable fixation loop 550. More particularly,as one or both of the openings 507, 509 constricts, a terminal end 550 tof the loop 550 moves towards the body 200, the terminal end 550 t beingat a location approximately where the two loop portions 501, 503 offilament are engaged with each other. A person skilled in the art willrecognize that the filament may move such that the terminal end 550 t isnot necessarily at a location where the two loops 501, 503 of filamentare engaged. For example, if one loop portion 507, 509 is significantlylarger than the other, the terminal end 550 t may not be the location atwhich the loop portions 507, 509 are engaged with each other. Thus, theterminal end 550 t of the loop 550 can more generally be a portion ofthe loop 550 that is approximately furthest away from the body 200, andin at least some instances it can be the location at which the loopportions 507, 509 are interconnected.

Further, the configuration illustrated in FIG. 2 is configured such thattension or force applied to the body 200, and/or to the adjustablefixation loop 550, in an attempt to expand the adjustable fixation loop550 can be prevented because such applied tension or force can causetension on the bridge portion 505, which in turn can constrict or lockthe two knots 520, 540. The foregoing notwithstanding, the presentdisclosure contemplates the ability to “unlock” the knots 520, 540 suchthat the constriction of the loop 550 can, optionally, be reversed, asdescribed in greater detail below.

In operation, the tails 502, 504 of the suture 500 may be pulled ontogether or in alternating fashion to reduce the length of theadjustable fixation loop 550 as desired. After a desired location of theadjustable fixation loop 550 is achieved, a force can be applied to theadjustable fixation loop 550 to create tension and cause the knots 520,540 to constrict against the slidable portion of the suture 500 (e.g.,the suture tails 502, 504 passing through their respective knots 520,540), thus maintaining the length of the adjustable fixation loop 550.

The knots 520, 540 knots in the construction of the loop 550 allow fornon-spliceable suture 500 to be used in the creation of the one-wayadjustable fixation loop 550. Even if the suture 500 is spliceable, theconstruct 400 configuration can be such that no splices are used, atleast with respect to where the knots 520, 540 are located. The use ofknots as opposed to splices provides enhanced security and greaterversatility for manufacturing a one-way constricting loop because itallows for the use of sutures that are not compatible with alternativelocking mechanisms, such as splices, among other benefits. Accordingly,the knots 520, 540 provided for herein can be described as beingunspliced since they do not contain splices as previously used inmedical applications. The implant 600, and the other disclosedconfigurations, or components thereof (e.g., various configurations ofsuture constructs), allow the knots 520, 540 to work independent of thebody 200 (e.g., a primary fixation device, cortical button, anchor, orplate). This arrangement increases the compatibility of the adjustablefixation loop 550 to be used in conjunction with many different types offixation devices, as well as helping to isolate and/or protect the knots520, 540 when a user trims the tails 502, 504 due, at least in part, tothe knots 520 being disposed on one side of the body 200 and the tails502, 504 on the other side of the body 200. Further, the use of knots520, 540 as opposed to splices provides for a construct 400 that has ashorter locking mechanism. Typical splices are about 17 millimeters inlength, as opposed to the knots 520, 540, which are approximately in therange of about 2 millimeters per knot to about 3 millimeters per knot.The reduced length of the knots takes up less loop length, and thusprovides for greater adjustability in use.

In the illustrated embodiment the surgical construct 400 is formed froma single filament. A person skilled in the art will understand thedisclosures provided for herein can be adapted for formation usingmultiple filaments though. For example, in some instances, a bridgeportion akin to the bridge portion 505 can be formed by tying orotherwise connecting two separate filaments together, each filamenthaving one knot, one looped portion, and one sliding tail, akin to theknots 520, 540, looped portions 501, 503, and sliding tails 502, 504,formed therein. The use of a single filament can provide benefits inease of manufacturing and/or formation, strength, and reliability, amongothers. Notably, to the extent any illustrations herein appear to showdifferent colored or shaded filaments, such differences exist toaccentuate the differences between the portions of the filament beingused for the various features (e.g., tail, loop portion, etc.); theillustrated embodiments are each formed from a single filament.

FIG. 3 illustrates one embodiment of a body 200 for used in conjunctionwith the suture constructs provided for in the present disclosure. Thebody, also known as a “cortical button,” 200 can have an elongate,somewhat rectangular shape with rounded or curved terminal ends 202,204. A plurality of through-holes can be formed in the body extendingbetween a first side 206 and a second, opposing side 208. A firstthrough-hole 210 and a second through-hole 212 can be adjacent to oneanother and positioned such that their centers lie along a longitudinalaxis 214 of the body 200. A third through-hole 216 can be positionedbetween the first through-hole 210 and the second through-hole 212, andits center can be offset by a distance from the longitudinal axis 214,as shown in the figures. The body 200 can also include fourth and fifththrough-holes 218, 220 positioned outside the first and secondthrough-holes 210, 212 near the terminal ends 202, 204 of the body.These through-holes can also be centered along the longitudinal axis214.

As shown, the first through fourth through-holes 210, 212, 218, 220 canhave diameters that are substantially the same, and a space separatingthe adjacent through-holes can be substantially the same for eachadjacent pair. A length L of the body 200 can be defined by a distancebetween the terminal ends 202, 204 and a width W can be defined by adistance between first and second sidewalls of the body 200 extendingalong the first or second surfaces 206, 208. The body 200 can also havea thickness T defined by a distance between the first and secondsurfaces 206, 208, as shown in FIG. 3.

In some embodiments, the length L of the body 200 can be in a range ofabout 5 mm to about 20 mm, the width W can be in a range of about 2 mmto about 6 mm, and the thickness T can be in a range of about 1 mm toabout 3 mm. In one exemplary embodiment, the length L can be about 12mm, the width W can be about 4.25 mm, and the thickness T can be about 2mm.

Diameters of the through-holes 210, 212, 216, 218, 220 can be in a rangeof about 1 mm to about 2 mm. The diameters of the first and secondthrough-holes 210, 212 can be selected such that a knot formed from asuture length is unable to pass through the hole. Further, in someembodiments the third through-hole 216 can be smaller than the first andsecond through-holes 210, 212. For example, in one embodiment thediameters of the first, second, fourth, and fifth through-holes 210,212, 218, 220 can be about 1.6 mm, and the diameter of the thirdthrough-hole 216 can be about 1.2 mm.

The body 200 can include one or more features that allow easiermanipulation of suture lengths threaded therethrough. For example, a topedge 222 or a bottom edge 224 of any of the through holes 210, 212, 216,218, 220 can be chamfered or rounded so as to ease threading of a suturelength therethrough and reduce the possibility of damage to a suturelength from contact with a sharp-edged corner. In addition, one or morecut-outs can be provided on the second surface 208 of the body 200 tofacilitate pulling a suture length through one of the plurality ofthrough-holes when the second surface 208 is, for example, pressedagainst the outer surface of a bone.

In some embodiments the body 200 can include recesses on the secondsurface 208 to receive the knots 520, 540 of the construct 400 when thebody 200 is pressed against a surface, such as a bone. Such aconfiguration can prevent the knots 520, 540 from interfering withcontact between the second surface 208 and the surface of the bone, orat least minimizing the impact of the knots 520, 540 on such contact.

The body 200 illustrated in FIG. 3 is merely one example of a bodyaccording to the teachings provided herein. A body configured to beassociated with a suture length to create a surgical implant asdescribed herein can have a variety of different shapes, sizes, andfeatures, and can be made of a variety of different materials. Thesevarious shapes, sizes, and materials can depend, at least in part, oncharacteristics of other components with which the body is used, such asthe suture length, the soft tissue graft type, etc. The shape, size, andmaterial can also depend on the particular type of procedure being usedto implant the body. Thus, while in the illustrated embodiment the body200 is somewhat rectangular having curved terminal ends 202, 204, inother embodiments the body can be substantially tubular or have any of avariety of other shapes. Configurations beyond cortical buttons are alsopossible, and thus the term “body” is by no means limited to justinclude cortical buttons. Various anchors, plates, and other fixationdevices known to those skilled in the art can be used in conjunctionwith the suture constructs (e.g., construct 400) provided for herein, orotherwise derivable from the present disclosures, to form adjustablefixation implants like the implant 600.

Additionally, the placement of the plurality of through-holes formedthrough the body 200 can be varied as well. For example, in theillustrated embodiment the longitudinal axis 214 is shown as a centrallongitudinal axis of the body. However, in other embodiments the axis214 may be offset toward one side of the body. The plurality ofthrough-holes can similarly be offset, or can be angled with respect tothe body 200. Further, the first and second through-holes 210, 212 neednot necessarily be centered along the same axis as the fourth and fifththrough-holes 218, 220. In some instances, fewer or more through-holescan be used. For example, in some instances, the third through-hole 216may be omitted. In instances in which the third through-hole 216 isused, however, typically the center of the third through-hole 216 shouldbe offset from whatever axis is defined by the centers of the first andsecond through-holes 210, 212.

The descriptions and illustration of an implantable body provided inconjunction with FIG. 3 are merely examples of surgical implants forsecuring soft tissue to bone that can be used in conjunction with thesuture constructs provided for herein (e.g., the suture construct 400).Non-limiting examples of surgical implants, as well as methods, forsecuring soft tissue to bone, are further provided below, as well inU.S. Pat. Nos. 9,974,643 and 9,757,113, the contents of each which ishereby incorporated by reference in their entireties. More particularly,the techniques for performing the procedures, and the types of implantbodies disclosed therein, can be used in conjunction with the sutureconstructs, and related techniques, disclosed herein.

FIGS. 4A and 4B illustrate the surgical construct 400 of the implant600, the construct 400 including the one-way adjustable loop 550constructed using two FIG. 8 noose knots 520, 540. As shown, thesurgical construct 400 can be made from a single length of suture 500with the first tail 502 extending from the first knot 520 and the secondtail 540 extending from the second knot 540. The knots 520, 540 can betied in two sections of the suture 500 such that extending from opposedor opposite sides of the knot are tails 502, 504 and adjustable loopportions, or loops, 501, 503, the loop portions defining the openings507, 509. The loops 501, 503 can be closed loops, defined by therespective knots 520, 540. As shown, ends of the loop portions 501, 503(illustrated at the terminal end 550 t) can be linked to form theone-way adjustable fixation loop 550, which itself defines the opening552. In the illustrated embodiment, the loop portions 501, 503 arelinked by passing the filament 500 from one loop portion (e.g., the loopportion 503) through an opening (e.g., the opening 507) defined by thefilament 500 from the other loop portion (e.g., the loop portion 501).As a result, each loop portion 501, 503 passes through the respectiveopenings 507, 509 defined by the filament 500 of the other loop portion501, 503. Other ways of linking one loop portion to the other may alsobe possible provided that such configurations allow the filament 500 ofthe loop portions 501 and/or 503 to advance towards the knots 520 540(and/or a fixation body when the construct 400 is used in conjunctionwith a fixation body) to decrease the size of the opening 552 defined bythe one-way adjustable fixation loop 550. In operation, tension oneither of the first and second tails 502, 504 can cause reduction in thecorresponding openings 507, 509 of the first and second adjustable loopportions 501, 503, which in turn can reduce a size of the opening 552defined by the one-way adjustable fixation loop 550.

The knots 520, 540 can be formed on the filament 500 in many differentmanners. In the illustrated embodiment, shown in greater detail in FIG.4B, the knots 520, 540 are formed as FIG. 8 noose knots. More generally,the knots 520, 540 can most aptly be classified as a type of runningknot and/or single strand single loop slipknots. These knots, whenarranged as in the one-way surgical construct 400, can exhibit aself-locking behavior due to, for example, a majority of tension appliedto 552 being directed to the knots 520, 540 opposed to the tails 502,504 on which they are running. The illustrated embodiments provide someexemplary self-locking knots that allow for the knots to be used in aone-way configuration while still having the ability to be reversed ifdesired, including the FIG. 8 noose knot (see FIGS. 4A-7B), the extendedFIG. 8 noose knot (see FIGS. 8A and 8B), and prusik-style knots (seeFIGS. 9 A and 9B). The illustrated embodiments are by no means limitingon the type and/or number of knots that can be used as knots (e.g.,knots 520, 540) in conjunction with the suture constructs (e.g., theconstruct 400) provided for herein to achieve the desired functionalityof the constructs. A person skilled in the art, in view of the presentdisclosures, will recognize other knots that are suitable for use inconjunction with the constructs and implants of the present disclosure.Further, the bridge portion 505 connects the first knot 520 to thesecond knot 540 and tension on the bridge portion 505 can constrict theknots 520, 540 and prevent expansion of the one-way adjustable fixationloop 550.

Manipulation of the single filament 500 to form each of the tails 502,504, the loop portions 501, 503, the knots 520, 540, and bridge portion505 can be achieved in a variety of manners. The order by which thevarious features (e.g., tails, loop portions, knots, bridge portion,etc.) of the construct 400 are formed is not typically critical. Asgenerally shown, the single filament 500 includes two terminal ends,which end up being the tails 502, 504. In one exemplary embodiment, thefilament 500 extends from the tail 502, is formed into the first loop501, and is tied around tail 502 to form the knot 520 and opening 507.The filament 500 can exit to the first knot 520 and can be tied intoknot 540 forming bridge 505. The working end of the filament 500 can bethreaded through opening 507 and a bend can be made around loop 501 toform loop 503. The working end can be returned and passed through knot540 to form opening 509 and tail 504.

In some embodiments, and as shown in FIGS. 10A-10C and 11, soft tissuemay be hung through the one-way adjustable fixation loop 550, therebycoupling the soft tissue to the loop 550, and more broadly a repairimplant (e.g., the implant 600). Any number of techniques can be used toassociate soft tissue with the loop 550, creating a coupledconfiguration in which movement of the loop 550 results in movement ofthe soft tissue. In some embodiments, the one-way adjustable fixationloop 550 can be suspended from a primary fixation device, such as thecortical button 200 or plate, by the bridge portion 505 of the suture500 between the two knots 520, 540. In other embodiments, as describedin greater detail below, the construct 400 can be operated by itself,without any fixation devices coupled to it. In still other embodiments,as also described in greater detail below, the construct 400 can beoperated with a plurality (i.e., two or more) fixation devices. Oneexample of such a configuration is provided for in FIG. 5.

FIG. 5 is an illustration of one embodiment of a surgical implant 700including the suture 500 having the one-way adjustable loop 550 formedby the two loop portions 501, 503 and knots 520, 540, as well as twocortical buttons 200, 200′. The second body 200′ can be threaded onto orotherwise associated with the adjustable fixation loop 550 usingtechniques known to those skilled in the art for associating a fixationbody with suture. In the illustrated embodiment, the loop portion 503 isthreaded through one through-hole 210′ of the body 200′ and back througha second through-hole 212′ of the body 200′. The second body 200′ can beused in a variety of contexts, including but not limited to pull twosides of a bone, or two separate bones, together, by selectivelyapplying tension to one or both of the tails 502, 504. Further,additional non-limiting examples of implant configurations utilizingmultiple fixation bodies are described below with respect to FIGS.12A-12C.

The construct 400 itself can be used without fixation bodies to achievesimilar functions, such as drawing two bones together. More generally,the construct 400 can be used with other components of a body beyondbones (e.g., tissue), and even in contexts outside of a surgicalprocedure, and thus with one or more objects. Some non-limiting examplesof the types of procedures that can benefit from using a plurality offixation bodies in conjunction with the constructs (e.g., the construct400) disclosed herein can include AC joint repairs, bunion repairs, andankle syndesmosis repairs. Although discussion herein primarily focuseson use in the medical field, a person skilled in the art will appreciatethat the suture constructs provided for herein can have applications inmany fields and industries as they can generally be used to advance oneor more objects towards a fixed location and/or advance one or moreobjects towards another object(s).

FIG. 6 illustrates one exemplary embodiment for forming a FIG. 8 nooseknot from a suture 700. As shown, the suture 700 includes a terminal end701 t. The suture 700 is formed into a FIG. 8 configuration 708, withthe terminal end 701 t extending through a top half 708 a of the FIG. 8as it completes the FIG. 8 shape, as shown at a location E. The suture700 can pass through the top half 720 a of the FIG. 8 at least once, asshown at a location F, and through a bottom half of the FIG. 8 at leasttwice, as shown at locations G and H. In the context of the constructsprovided for herein, the portion of the suture 700 that is on anopposite end of the suture as the terminal end 702 t, identified in FIG.6 as portion 701 t, can be used to form the remaining portions of asuture construct (e.g., the construct 400) in accordance with thepresent disclosures, and thus does not typically represent an opposedterminal end of the suture 700. Further, in the context of theconstructs provided for herein, the portion of the filament 700identified as 703 can be a loop portion and the terminal end 702 t canbe a tail.

FIG. 7A shows the suture 700 tied with the FIG. 8 noose knot 720 of FIG.6 to form the loop portion 703, a sliding tail or post 702 (associatedwith portion 702 t of FIG. 6), and a constricting tail 701 (associatedwith the terminal end 701 t of FIG. 6). In operation, the sliding tail702 is free to be pulled through the FIG. 8 noose knot 720 to constrictthe loop portion 703, i.e., it causes an opening 709 defined by the loopportion 703 to get smaller. As described above, such movement canlikewise cause an opening defined by the loop portion 703 and aninter-connected loop portion (not illustrated) to also get smaller. Byapplying tension on the constricting tail 701, as shown in FIG. 7B, thesuture 700 can be placed in a locked configuration. More particularly,opposing tension can be applied to the constricting tail 701 and theloop 703 by applying forces in directions P and P′, respectively, theforces constricting the knot 720 such that the tail 702 kinkssubstantially perpendicular to the direction the tail 702 naturallyexits the knot 720 and/or substantially perpendicular to the forceapplied to the loop portion, causing the knot to constrict or lock, thuspreventing further movement of the sliding tail 702 through the FIG. 8noose knot 720. A person skilled in the art will recognize the forceapplied to the constricting tail 701 to place the knot 720, or moregenerally a suture construct that includes the knot 720, in a lockedconfiguration does not necessarily have to be in a direction that issubstantially perpendicular to the direction the tail 701 naturallyexits the knot 720 and/or substantially perpendicular to the slidingtail 702, and that there are other ways by which the knot 720 can beplaced in a locked configuration.

FIG. 8A shows a suture 800 tied with an extended FIG. 8 noose knot 820to form a loop portion 803, a constricting tail or post 801, and asliding tail or post 802. In operation, the sliding tail 802 is free tobe pulled through the FIG. 8 noose knot 820 to constrict the loopportion 803, i.e., it causes an opening 809 (FIG. 8B) defined by theloop portion 803 to get smaller. As described above, such movement canlikewise cause an opening defined by the loop portion 803 and aninter-connected loop portion (not illustrated) to also get smaller. Byapplying tension on the constricting tail 801, as shown in FIG. 8B, thesuture 800 can be placed in a locked configuration. More particularly,tension can be applied to the constricting tail 801 and loop 803 byapplying opposing tensile forces in directions R and R′, respectively,to cause the knot 820 to constrict or lock, thus preventing furthermovement of the sliding tail 802 through the extended FIG. 8 noose knot820. A person skilled in the art will recognize the force applied to theconstricting tail 801 to place the knot 820, or more generally a sutureconstruct that includes the knot 820, in a locked configuration does notnecessarily have to be in the direction(s) R and R′, and that there areother ways by which the knot 720 can be placed in a lockedconfiguration. Compared with the FIG. 8 noose knot 720, the extendedFIG. 8 noose knot 820 reduces bending of the slidable tail 802. Similarto the FIG. 8 noose knot 720, the constricting tail 801 can become partof a bridge portion, and the knot 820 can also be reversible such thatthe sliding tail 801 can be moved again.

FIG. 9A shows a suture 900 tied with a prusik-style knot 920 to form aloop portion 903, a constricting tail 902, and a sliding tail or post901. The prusik-style knot 920 can be created, for example, by piercingthe end of the suture 900 through a central portion of the suture 900.In operation, the sliding tail 901 is free to be pulled through theprusik-style knot 920 to constrict the loop portion 903, i.e., it causesan opening 909 defined by the loop portion 903 to get smaller. Asdescribed above, such movement can likewise cause an opening defined bythe loop portion 903 and an inter-connected loop portion (notillustrated in FIG. 9A) to also get smaller. By applying tension on theconstricting tail 902 and loop 903, the suture 900 can be placed in alocked configuration. More particularly, opposing tension can be appliedto the constricting tail 902 and loop 903 by applying forces indirections K and K′ to cause the knot 920 to constrict or lock, thuspreventing further movement of the sliding tail 901 through theprusik-style knot 920. A person skilled in the art will recognize theforce applied to the constricting tail 902 to place the knot 920, ormore generally a suture construct that includes the knot 920, in alocked configuration does not necessarily have to be in the direction asexemplified but, generally, simply develop tension in the constrictingportion of the knot 920. A person skilled in the art will furtherrecognize that there are other ways by which the knot 920 can be placedin a locked configuration. Similar to the knots 720 and 820, the tail902 can become part of a bridge portion, and the knot 920 can also bereversible such that the sliding tail 901 can be moved again and/or theloop portion 903 can be expanded.

The prusik-style knot 920 may be stacked in series to increase securityas needed, and FIG. 9B shows a surgical construct 400′ that includes twoprusik-style knots 921, 922 forming a first loop portion 501′ of anadjustable fixation loop 550′ defining an opening 552′, and twoprusik-style knots 941, 942 forming a second loop portion 503′ of theadjustable fixation loop 550′. Comparing FIG. 9A to 9B, the equivalentof the constricting tail 902 can form a bridge portion 505′, theequivalent of the sliding tail 901 can form first and second tails 502′,504′, and the equivalent of the loop portion 902 can form first andsecond loop portions 501′, 503′. When used with a cortical button (notshown), for example, such as a free-floating cortical button, theincreased cross-sectional area created by the knots 921, 922, 941, 942suspended below the button can act as a locating mechanism within a bonetunnel, more closely constraining the location of the button withrespect to a tunnel aperture of the tunnel. This can help to center thebody about the tunnel and reduce the likelihood of compromised fixationof the primary fixation compared to solutions where the suture below thebutton is straight. In fact, any of the configurations provided forherein can allow the knots (e.g., the knots 520, 540, 720, 820) to beused as a locating mechanism.

Just as in FIG. 9B, in which the equivalent of the tails 901, 902 of theprusik-style knot 920 can be used to form the first and second tails502′, 504′ and the bridge portion 505′, respectively, and the equivalentof the loop portion 903 can be used to form the first and second loopportions 501′, 503′, when a FIG. 8 noose knot 720 or an extended FIG. 8noose knot 820 is used in the surgical construct 400, the tails 502, 504of the surgical construct 400 can be the sliding tails 702, 802, theloop portion 501, 503 of the surgical construct 400 can be the loopportions 703, 803, and the bridge portion 505 of the surgical construct400 can be the constricting tails 701, 801.

Further, the present disclosure allows for the tails 702, 802, 901 to bemoved back to a configuration more akin with that illustrated in FIGS.7A, 8A, and 9A, respectively, to remove the knots 720, 820, 920 from thelocked configuration, thus allowing the sliding tails 702, 802, 901 tobe moved again. When the constricting tail 701, 801, 902 is in anunlocked configuration, tension can be applied to the loop portion 703,803, 903 to allow the opening 709, 809, 909 defined by the loop portion703, 803, 903 to be expanded.

FIGS. 10A-10C are illustrations of steps for tightening the loop of oneexemplary embodiment of a one-way adjustable loop. FIG. 10A shows theimplant 600 that includes the surgical construct 400 and the body 200with a soft tissue 110 coupled to the adjustable fixation loop 550. Theadjustable fixation loop is formed by the loop portions 501 and 503.FIG. 10B illustrates a tightening or constricting operation where aforce applied in a direction S to either or both of the first and secondtails 502, 504 of the surgical construct 400 constricts the adjustablefixation loop 550, decreasing a size of the opening 552 and drawing thesoft tissue 110 towards the body 200, to a position shown in FIG. 10C.More particularly, tension applied to the tail 502 can constrict theloop portion 501, and tension applied to the tail 504 can constrict theloop portion 503. In FIG. 10C, a force applied in a direction T to thesoft tissue 110 does not result in the adjustable fixation loop 550expanding because the resulting tension causes the bridge portion 505 ofthe surgical construct 400 to constrict the knots 520, 540, meaning theknots 520, 540 are in a locked configuration. As described elsewhereherein, the knots 520, 540 can be moved to an unlocked configuration, inwhich case a force applied in the direction T, as well as other forcesapplied to the loop 550, can cause such expansion.

The use of the knots 520, 540 permits greater versatility formanufacturability of the one-way constricting loop constructs 400 byenabling the use of sutures 500 that are not compatible with alternativelocking mechanisms (e.g., splices). One such example is sutures withsolid cores, such as DePuy Synthes Dynacord™ suture, available fromDePuy Synthes Sports Medicine (Mitek) of Raynham, Mass. Dynacord™ sutureis constructed with a solid core which is essential for the suture'sability to contract when hydrated. Additional information about suchsuture configurations is provided at least in U.S. Pat. No. 8,870,915 toMayer et al., the contents of which is incorporated by reference hereinin its entirety. The contraction behavior of the constructs provided forherein (e.g., the construct 400) may be used in conjunction with theDynacord technology to resist losses of the repair due to creep,reapproximate tissue between which a gap has formed or maintain acompressive force on approximated tissue. The presence of a solid coreand its required intimate relationship with the sutures braid appeal forlocking mechanisms such as knots that are external to the suture's core.

The tightening steps described above, for instance in conjunction withFIGS. 10A-10C, can also be used in conjunction with surgical procedures.The surgical constructs and implants provided herein can be used in avariety of procedures to secure a soft tissue graft to bone. One commonprocedure is the repair of a torn or ruptured ACL in a patient's knee.An exemplary repair procedure can include forming a bone tunnel througha patient's tibia 106 and femur 108 (see FIG. 1) in a manner known inthe art. This can produce, for example, the bone tunnel 130 illustratedin FIG. 11.

The implant 600 provided for in FIG. 11 includes the suture construct400 and the fixation body 200. The bridge portion 505 that extendsbetween the two knots 520, 540 can be hung across the body 200, which isseated on the far side of the bone 108 once implanted. Each knot 520,540 has the suture tails 502, 504, respectively, extending from one sideof the knot, the tails extending through the button 200, and thefilament that forms the loops 501, 503 extending from an opposite sideof the knots 520, 540, respectively. The loops 501, 503 form aninterlocked loop portion, illustrated at the terminal end 550 t (FIG. 2)that results in the one-way adjustable fixation loop 550.

The implant 600 can be prepared by coupling a ligament graft taken froma cadaver or the patient's own tissue, e.g., the soft tissue 110, to thebody 200 by way of the one-way adjustable fixation loop 550. The softtissue 110 is hung over, or otherwise associated with, the one-wayadjustable fixation loop 550 and tension can be applied to the suturetails 502, 504 to reduce the size of the opening of the loop 550 untilthe soft tissue 110 is at a desired location with respect to the bonetunnel 130.

More particularly, after the tunnel 130 is drilled through the bone 108at the repair site, the implant 600 can be introduced. In someinstances, the combination of the suture construct 400 and body 200 mayalready be coupled together to form the implant 600. In other instances,the suture construct 400 can be associated with one or more bodies 200in conjunction with performing the repair.

The body 200 can be introduced into the bone tunnel of the patient'stibia 106 and pulled through the tibia and femur 108 until the body 200emerges on an outer portion of the patient's femur. In order to pull thebody 200 through the bone tunnel, a shuttle suture (not shown) can bethreaded through the fourth through-hole 218 (see FIG. 3) that is nearthe first (front) terminal end 202 of the body 200. The shuttle suturecan be used to pull the body through the bone tunnel 130 approximatelyalong its longitudinal axis 214 to minimize the cross-sectional area ofthe body. Pulling the body 200 in this manner can also pull the fixationloop 550 and graft 110 into the patient's body.

After the body 200 emerges from the bone tunnel 130 at an outer surfaceof the femur 108, the body 200 can be flipped into an orientation thatplaces the second side 208 flush against the outer surface of the femursuch that the body 200 cannot reenter the bone tunnel 130. Flipping theorientation of the body 200 can be accomplished by pulling on a rotationsuture (not shown) that can be threaded through the fifth through-hole220 (see FIG. 3) near the second (rear) terminal end 204 of the body200. It should be noted that both shuttle and rotation sutures can bethreaded through the fourth and fifth through-holes 218, 220, or otherthrough-holes if desired, prior to introducing the body 200 into a bonetunnel. After the body 200 has been pulled through the bone tunnel andflipped to sit flush against an outer surface 302 of the femur 108 (asshown in FIG. 11), the shuttle and rotation sutures can be removed bysimply pulling on a free end thereof.

As shown in FIG. 11, and similar to described above with respect toFIGS. 10A-10C, the terminal ends 502, 504 can be tensioned in thedirection of arrow 304 to reduce the size of the one-way fixation loop550 and draw the ligament graft 110 into the bone tunnel 130 formed inthe femur 108. The size of the fixation loop 550 can be reduced until adesired amount of the graft 110 resides within the bone tunnel 130.Tensioning the terminal ends 502, 504 of the suture length 500 drawssuture through the corresponding knot 520, 540 positioned below the body200. The bridge portion 505 of suture 500 connects the first knot 520 tothe second knot 540 such that movement of the body 200 away from thefemur 108 is prevented by the tensioning of the bridge portion 505causing the two knots 520, 540 to lock and secure the body against thefemur 108. If desired, additional supplementary fixation (e.g., by wayof one or more half hitch knots) can be applied to the tails 502, 504.

To complete the procedure, the terminal ends of the ligament graft 110can be secured within the bone tunnel 130 formed in the patient's tibia106 in any of a variety of manners known in the art. In certainembodiments, the terminal ends 502, 504 can be joined together toprovide a user with a single suture strand for tensioning. This can beaccomplished in a number of manners known in the art. In someembodiments, for example, the terminal ends 502, 504 can be associatedtogether, such as by passing one into a volume of the other, to form asingle terminal end. When the desired depth/repair tension is achieved,the suture tails 502, 504 can be trimmed to length. Additional detailsrelated to implantation techniques that can be used in conjunction withthe present disclosures, including but not limited to details thatfurther expand upon the disclosed techniques and provide alternatives tothe described techniques, are provided in U.S. Pat. Nos. 9,974,643 and9,757,113, the contents of each which is incorporated by referenceabove.

As discussed above, embodiment of the present disclosure includes theuse of two or more fixation bodies. The bodies may be of a closedgeometry where the loop is threaded to the buttons when it is assembled(as illustrated in FIG. 5), or an open geometry where the loop is hungover a portion of the button, as shown in FIGS. 12A-12C. A personskilled in the art will further recognize other techniques that can beused to associate the constructs provided for herein with fixationbodies.

FIG. 12A shows an implant 1110 including two open-geometry fixationbodies or buttons 1111, 1111′ and the suture 500 arranged with theone-way adjustable fixation loop 550 to form the surgical repairconstruct 400. The open-geometry buttons 1111, 1111′ include gaps 1112in their though-holes to facilitate the construction of the implant 1110without threading the suture 500 through closed through-holes. Thisenables the suture 500 to be tied to form the surgical construct 400having the one-way adjustable fixation loop 550 in advance of assemblingthe buttons 1111, 1111′ to the suture 500 and/or more easily associatingand disassociating the construct 400 from the fixation bodies 1111,1111′.

FIG. 12B is another embodiment of an implant 1120, in this instancecoupling the suture 500 of the surgical construct 400 having the one-wayadjustable fixation loop 550 to each of the closed-geometry fixationbody or button 200 and another example of an open geometry fixation bodyor plate 1121. The plate 1121 includes lateral gaps 1120 for couplingthe open geometry plate 1121 to the suture 500 after the suture has beenthreaded though the closed-geometry button 200, as described herein.Again, the open geometry can allow the construct 400 to be more easilyassociated and disassociated from the fixation body 1121.

FIG. 12C is yet another embodiment of an implant 1130, in this instancecoupling the suture 500 of the surgical construct 400 having the one-wayadjustable fixation loop 550 to each of the closed-geometry fixationbody or button 200 and another example of a closed geometry fixationbody or button 1131. The button 1131 includes internal passageways 1132for threading the suture 500 though the closed geometry button 1131. Theinternal passageways 1132 can better protect the suture 500 from frayingor other damage during the course of a procedure, and/or once theimplant is implanted in the body.

FIG. 13 is an illustration of an implant 1200 including the suture 500forming the one-way adjustable fixation loop 550, the single corticalbutton 200, and a utility stitch 1201. For applications where overtensioning is a concern and reversing the tension is advantageous (e.g.,procedures involving the medial patella femoral ligament), the utilitystitch 1201 may be added to the knots 520, 540, for instance by passingor extending limbs of the utility stitch 1201 through the knots 520, 540such that when tension is applied to the utility stitch 1201, the knots520, 540 can be open to permit the button 200 to slide, therebyexpanding the adjustable fixation loop 550. The utility stitch 1201 canbe threaded through one of the through-holes of the body 200, as shownthe third through-hole 216, which enables tension applied to the utilitystitch 1201 to pull on the body 200 to expand the adjustable fixationloop 550. Due to interference in loops caused by compressive forces atthe loop junctions a toggling technique, illustrated in FIGS. 14A-14C,may be employed to prevent the migration of the junction into acompressed region (i.e., where the soft tissue is hung through the loop550).

FIG. 14A shows a soft tissue 110 hung on the adjustable fixation loop550, and force applied, indicated by arrow 1301, to the utility stitch1201 to relax the knots 520, 540 and expand the adjustable fixation loop550 by drawing the button 200 away from the soft tissue 110, indicatedby arrow 1302. Afterwards, and as shown in FIG. 14B, force applied,indicated by arrows 1303 to the first and second tails 502, 504 canconstrict the adjustable fixation loop 550 by drawing the button 200toward the soft tissue 110, as indicated by arrow 1304. Finally, asshown in FIG. 14C, even after the adjustable fixation loop 550 has beenconstricted, and the knots 520, 540 locked, force applied to the utilitystitch 1201, for instance as indicated by arrow 1301, still can relaxthe knots 520, 540 and expand the adjustable fixation loop 550 bydrawing the button 200 away from the soft tissue 110.

One skilled in the art will appreciate further features and advantagesof the disclosure based on the above-described embodiments. Accordingly,the disclosure is not to be limited by what has been particularly shownand described, except as indicated by the appended claims. Allpublications and references cited herein are expressly incorporatedherein by reference in their entirety.

What is claimed is:
 1. A suture construct formed from a suture filament,comprising: a first knot formed in the suture filament to create a firstloop extending from the first knot, the first loop defining a first loopopening; a first tail of the suture filament extending from the firstknot; a bridge portion of the suture filament extending from the firstknot; a second knot formed in the suture filament to create a secondloop extending from the second knot, the second loop defining a secondloop opening, and a portion of the second loop passing through the firstloop opening to define an adjustable loop of the suture construct, theadjustable loop defining an adjustable loop opening; and a second tailof the suture filament extending from the second knot, wherein the firsttail is configured to slide with respect to the first knot to reduce asize of the first loop opening, and thus reduce the size of theadjustable loop opening, wherein the second tail is configured to slidewith respect to the second knot to reduce a size of the second loopopening, and thus reduce the size of the adjustable loop opening, andwherein the bridge portion of the suture filament connects the firstknot to the second knot and is configured to prevent expansion of theadjustable loop opening when the suture is manipulated into a lockedconfiguration.
 2. The suture construct of claim 1, wherein at least oneof the first knot or the second knot comprises a self-locking knot. 3.The suture construct of claim 2, wherein the self-locking knot comprisesat least one of a FIG. 8 noose knot or an expanded FIG. 8 noose knot. 4.The suture construct of claim 2, wherein the self-locking knot comprisesat least one prusik-style knot.
 5. The suture construct of claim 1,wherein the suture filament is unspliced at locations of the first andsecond knots.
 6. The suture construct of claim 1, further comprising asecond suture filament configured to capture a portion of the first knotand the second knot, with a first limb of the second suture filamentextending to the first knot and a second limb of the second suturefilament extending to the second knot such that tension on at least oneof the first or second limbs loosens the respective first or secondknots.
 7. The suture construct of claim 1, further comprising a fixationbody coupled to the bridge portion of the suture filament.
 8. The sutureconstruct of claim 7, further comprising a second fixation body coupledto the adjustable loop.
 9. The suture construct of claim 1, wherein thesuture further comprises an unlocked configuration, with the suturebeing configured to be moved between the unlocked configuration and theunlocked configuration by adjusting relative loading of at least one ofthe bridge portion, the first tail, or the second tail.
 10. A surgicalimplant, comprising: a fixation body having a longitudinal axisextending therealong, first and second sides, and first and secondthrough-holes; and a suture filament coupled to the fixation body, thesuture filament, comprising: a first portion having a first tailextending through the first through-hole, a first knot formed thereonand disposed on the first side of the body, and a first loop portionextending from the first knot, away from the body; a second portionhaving a second tail extending through the second through-hole, a secondknot formed thereon and disposed on the first side of the body, and asecond loop portion extending from the second knot, away from the body,the second loop portion being coupled to the first loop portion todefine an adjustable loop of the surgical implant; and a bridge portionextending from the first knot to the second knot, wherein the first andsecond knots are configured such that tension on the first tailconstricts the adjustable loop by constricting the first loop portionand tension on the second tail constricts the adjustable loop byconstricting the second loop portion, and wherein the first and secondknots are further configured such that tension on the bridge portionprevents expansion of the adjustable loop.
 11. The surgical implant ofclaim 10, wherein at least one of the first knot or the second knotcomprises a self-locking knot.
 12. The surgical implant of claim 10,wherein the suture filament is unspliced at locations of the first andsecond knots.
 13. The surgical implant of claim 10, wherein the fixationbody comprises a cortical button.
 14. The surgical implant of claim 10,wherein the bridge portion extends from the first knot, through thefirst through-hole, across the body, and through the second through-holeto the second knot.
 15. The suture construct of claim 14, furthercomprising a second fixation body, the second fixation body beingcoupled to the adjustable loop.
 16. The surgical implant of claim 10,wherein the surgical implant further comprises a second suture filamentthat captures a portion of the first knot and the second knot, with afirst limb of the second suture filament extending to the first knot,and a second limb of the second suture filament extending to the secondknot, and wherein the second suture filament is configured such thattension on at least one of the first or second limbs loosens therespective first or second knots.
 17. A method for preparing a surgicalimplant, comprising: forming a first knot in a first portion of a suturelength to form a first tail extending from one side of the first knotand a second portion of the suture length extending from an oppositeside of the first knot; forming a first loop from the second portion,the first loop being closed by way of the first knot; forming a secondknot in the second portion of the suture length to form a second tailextending from one side of the second knot and a third portion of thesuture length extending from an opposite side of the second knot; andforming a second loop from the third portion, the second loop beingclosed by way of the second knot, the second loop being interconnectedwith the first loop to define an adjustable fixation loop of the sutureconstruct.
 18. The method of claim 17, wherein the second portion of thesuture length comprises a bridge portion that extends between the firstknot and the second knot.
 19. The method of claim 17, wherein at leastone of the first tail or the second tail is configured to constrict asize of an opening defined by the adjustable fixation loop when tensionis applied thereto to constrict a size of first or second openingsdefined by the respective first or second loops.
 20. The method of claim17, further comprising: passing the first tail through a firstthrough-hole of a fixation body; passing the second tail through asecond through-hole of the fixation body; and passing the second portionof the suture length through at least two of the first through-hole ofthe fixation body, the second through-hole of the fixation body, or atleast one more through-hole of the fixation body.
 21. The method ofclaim 20, further comprising coupling the adjustable fixation loop to asecond fixation body.